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Published 10:15 19 Jan 2017 GMT
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Cullen attempted to assuage any fears that O'Brien could be out for longer than expected, last week, when he addressed the matter of him missing the Montpellier game with a tight calf. Queried after that comfortable home win over the French side, Cullen suggested O'Brien would be keen to feature this weekend.
O'Brien is willing but his body is not able. Jack Conan and Josh van der Flier are in at blindside and openside for Friday's encounter at Stade Pierre-Antoine.
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The fact that O'Brien is missing out on two big Champions Cup games in a row will do him no favours in terms of making Joe Schmidt's Ireland XV. Should O'Brien shake off is calf issues, he will be lacking in match fitness.
Being able to step into a Test match team is something that definitely played on Schmidt's mind last season. He said:
"We feel the pace of the [New Zealand] game will be very, very quick. We tried to select the guys [Jordi Murphy and Josh van der Flier] who we felt were match-fit and ready to go."The fact that O'Brien was forced to withdraw from the Ireland team to face Australia, last November, at late notice does also not bode well for his chances. Schmidt names his Six Nations squad, for the opening rounds, on Sunday.

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