Arsenal will fancy their chances at Southampton, who will take on Arsene Wenger's side without talisman Graziano Pelle.
The Italian misses out through injury, while defender Cedric is also sidelined. Republic of Ireland striker Shane Long and Cuco Martina start in place of the duo.
Long has only managed two league goals this season and would love to reproduce some of his international form against Arsene Wenger's men.
Arsenal are unchanged from the team that beat Manchester City at the Emirates Stadium.
Three points at St Mary's would see the visitors move to the top of the Premier League table.
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