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Published 19:26 15 Oct 2018 BST
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In the wing-back positions, Matt Doherty and Enda Stevens start.
Doherty was rarely involved against Denmark, but he could be a valuable attacking outlet if used correctly. Wolves channel the majority of their attacks down his side and Doherty has been one of the best players in his position in the Premier League this season.
Stevens grew into the match when he came off the bench at half-time on Saturday. The Sheffield United full-back was defensively solid and helped set-up Ireland's only effort on goal.
In midfield, Shaun Williams, Conor Hourihane and Jeff Hendrick start. There's no place for Cyrus Christie because he's a full-back, not a midfielder.
Williams scored against Wales in September and then impressed at the base of midfield against Poland in a friendly.
The Millwall midfielder was calm on the ball and precise with his passing. Ireland will need to do more than lump the ball away if they are to have any chance of beating Wales. Williams may not be a household name, but he is the type of player that could help the team get a grip on midfield. If not Williams, then David Meyler should start in that position.
Hourihane and Hendrick should start in the other midfield positions.
Hourihane has registered four assists already this season for Aston Villa and is a dead-ball specialist. Hendrick is at his best working as a box-to-box midfielder, rather than as a number 10 or sitting deep - the two roles he had to perform against Denmark.
Harry Arter is also an option, but the Cardiff City midfielder isn't particularly suited to a holding midfield role, the position he played in on Saturday night.
He seeks to press the opposition, and that can often leave space behind him. So, if Arter plays, it shouldn't be at the base of midfield.
Up front, we've opted for James McClean and Shane Long or Callum Robinson.
McClean was used as a wing-back and in central midfield against Denmark. The Derry-native arguably isn't really suited to either position, but Ireland could use his energy and aggression higher up the pitch if they are to try to press the Welsh backline.
O'Neill said on Monday that Long is a doubt for the match. The Southampton forward performed admirably against the Danes and was starved of service. If he is fit to play, he should start against Wales.
Although Ireland don't create any goal scoring chances, and he isn't a prolific goal scorer, Long's pace can unsettle opposition defences and he can help the team win free-kicks.
If Long doesn't make it, Robinson could get the nod. The Preston forward played quite well when he came on as a substitute against Denmark. He was tidy in possession and dropped deep trying to link-up play.
Unfortunately, the game may have come too soon for Sean Maguire. The former Cork forward only recently returned to action following a lengthy spell on the sidelines. But he may be an option from the bench in the second-half.
Here's the full XI:

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