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Published 15:16 28 May 2017 BST
Updated 15:19 28 May 2017 BST
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Ireland captain Seamus Coleman has a long-term injury while stand-in Robbie Brady is being spared the Stateside trip. The other strong option for O'Neill is Derby County captain Richard Keogh.
Here is the squad in full.
Goalkeepers: Colin Doyle, Darren Randolph Defenders: Cyrus Christie, Alex Pearce, Richard Keogh, Shane Duffy, Andy Boyle, Kevin Long, John Egan Midfielders: Eunan O'Kane, Alan Browne, Daryl Horgan, Conor Hourihane, Wes Hoolahan, Stephen Gleeson, Callum O'Dowda, James McClean Forwards: David McGoldrick, Daryl Murphy