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Published 10:07 23 Jan 2017 GMT
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Ulster's Paddy Jackson will be ready to deputise if Sexton comes up short in his race for fitness, while Schmidt has faith in Sexton returning as he has not opted to call up a third out-and-out out-half.
In uncapped news, there are places in the squad for Munster brothers Niall and Rory Scannell, with both men rewarded for their breakthrough heroics for the province with their first call-ups to the international stage while Andrew Conway has too been given a show of faith.
"It has been good to watch the players over the past two months and great to see many of them doing so well," Schmidt said.
https://twitter.com/IrishRugby/status/823469675078189060
"As always there were some difficult decisions but we feel that the group is a good mix with a number of key players having good experience and a number of newer players having gained valuable experience and confidence during the summer tour to South Africa and the recent Guinness Series."
There are 13 Munster men in the selection, which is the province's biggest representation since 2010.
England remain odds on to claim successive Six Nations champions while Ireland find themselves second favourites to lift the trophy come March.
Forwards (22)
Finlay Bealham (Buccaneers/Connacht) 6 caps
Rory Best (Banbridge/Ulster) (c) 100 caps
Jack Conan (Old Belvedere/Leinster) 1 cap
Ultan Dillane (Corinthians/Connacht) 8 caps
Tadhg Furlong (Clontarf/Leinster) 11 caps
Cian Healy (Clontarf/Leinster) 62 caps
Jamie Heaslip (Dublin University/Leinster) (vc) 91 caps
Iain Henderson (Ballynahinch/Ulster) 28 caps
Billy Holland (Cork Constitution/Munster) 1 cap
Dave Kilcoyne (UL Bohemians/Munster) 17 caps
Dan Leavy (UCD/Leinster) 1 cap
Jack McGrath (St. Mary's College/Leinster) 36 caps
Sean O'Brien (UCD/Leinster) 44 caps
Tommy O'Donnell (UL Bohemians/Munster) 12 caps
Peter O'Mahony (Cork Con/Munster) 37 caps
Donnacha Ryan (Shannon/Munster) 43 caps
John Ryan (Cork Constitution/Munster) 1 cap
Niall Scannell (Dolphin/Munster) *
CJ Stander (Munster) 10 caps
Devin Toner (Lansdowne/Leinster) 42 caps
James Tracy (UCD/Leinster) 1 cap
Josh van der Flier (UCD/Leinster) 5 caps
Backs (18)
Tommy Bowe (Belfast Harlequins/Ulster) 67 caps
Andrew Conway (Munster) *
Keith Earls (Young Munster/Munster) 54 caps
Craig Gilroy (Bangor/Ulster) 9 caps
Robbie Henshaw (Buccaneers/Leinster) 24 caps
Paddy Jackson (Dungannon/Ulster) 19 caps
Rob Kearney (UCD/Leinster) 72 caps
Kieran Marmion (Corinthians/Connacht) 9 caps
Luke Marshall (Ballymena/Ulster) 9 caps
Stuart McCloskey (Ballynahinch/Ulster) 1 cap
Luke McGrath (UCD/Leinster) 1 cap
Conor Murray (Garryowen/Munster) 53 caps
Tiernan O'Halloran (Buccaneers/Connacht) 3 caps
Garry Ringrose (UCD/Leinster) 3 caps
Rory Scannell (Dolphin/Munster) *
Jonathan Sexton (St Mary's College/Leinster) 63 caps
Andrew Trimble (Ballymena/Ulster) 69 caps
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