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Published 16:39 20 Nov 2015 GMT
Updated 21:05 20 Nov 2015 GMT
A 4-4-1-1 formation with Juan Mata, who has been involved in 30 goals since his January 2014 arrival at United.
The beauty of this team is that all four players have attacking ambitions and can switch in and out of the frontman duties. That leaves Bastian Schweinsteiger and Morgan Schneiderlin to conrol the tempo, as best they can, and shield the back four.
On the bench, van Gaal can call on Wilson if Plan A goes to the wall. Other options may include Andreas Pereira, moving Young into midfield and England U20 striker Ashley Fletcher.
After a solid start to life at Old Trafford, Depay has fallen afoul of his coach, appeared sulky in games and twice turned up late for team gatherings.
A partnership with the savvy Mata - with Ander Herrera probing nearby - could be the start of something most defences would struggle with. The extra responsibility in leading the line may be a release for the 21-year-old.
The formation here is 3-5-2, which van Gaal toyed with last season. Daley Blind and Young are more than capable of patrolling the tramlines.
Van Gaal has openly expressed his doubts on Wilson's ability to plough the frontline furrow for 90 minutes.
Still, that may not prevent him from starting the promising 19-year-old, who scored a brace on his debut in 2013/14.
Once again, Mata gets the No.10 role while there is plenty of attacking intent on the wings. Marcos Rojo and Lingard did well on the left against West Brom while linking Matteo Darmian and Ashley Young is an exciting prospect.
To add a touch more zip to the centre of midfield, Daley Blind gets the start alongside Morgan Schneiderlin while Phil Jones partners Smalling at centre back.