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Published 11:32 20 Jun 2016 BST
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Italy look set to make nine changes for the game in Lille, which Ireland must win to stand any chance of progression to the last-16, and, according to The Times, O'Neill will make four changes to his starting team.
Clark will miss out to Richard Keogh or Shane Duffy, Stephen Quinn will replace McCarthy, James McClean will come in for Wes Hoolahan and Shane Long will drop to the bench for Daryl Murphy, who has failed to score in his 21 appearances for Ireland.
The reported changes could also mean a change in formation. Here's how the team, if the reports are correct, could line-out. However, O'Neill is difficult to second guess.

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